Abstract: Objective To investigate the risk factors for bronchial asthma-chronic obstructive pulmonary disease overlap (ACO) complicated with depression. Methods A total of 141 stable ACO patients (included 60 cases in ACO group, 59 cases in stable COPD group and 22 cases in asthma group) hospitalized in our hospital from January 2017 to January 2018 were included in this study. Hamilton depression scale (HAMD)-17 questionnaire survey was conducted in ACO group, COPD group and asthma group. The percentage of forced expiratory volume in the first second (FEV1% pred) and the modified British medical research association dyspnea scale (mMRC) were measured in three groups of patients. According to HAMD-17 score, ACO group was divided into non-depression group (HAMD-17 score ≤ 7, n=15) and depression group (HAMD-17 score > 7, n=45). The possible risk factors of depression were analyzed in ACO patients. Results The HAMD-17 scores were significantly higher in ACO group than those in the COPD group and asthma group (P＜0.05). The proportion of depressive patients with mMRC ≥ 2 and FEV1% pred＜50% was higher than that of nondepressive patients (all P＜0.05). Logistic regression analysis showed that mMRC≥2 and FEV1%pred＜50% were independent risk factors for depression in ACO patients. Conclusion The severity of depression is more serious in the ACO patients than that in the COPD and the asthma patients. We should pay attention to screening depression in ACO patients.

Key words: asthma, pulmonary disease, chronic obstructive, depression, asthma-chronic obstructive pulmonary overlap, risk factors