Research progress on the interaction between endometrial diseases and the microbiota of reproductive and gastrointestinal tracts

doi:10.11958/20252544

Abstract

Abstract:

Pathological mechanisms of endometrial disorders, including endometriosis, endometrial carcinoma and chronic endometritis are complex. The intestinal flora, as the most important micro-ecosystem in human body, plays a key role in material metabolism, immune regulation and neuroendocrine control. The homeostasis of the female reproductive tract microbiota has been proven to be the foundation for maintaining reproductive health. The "gut-organ axis" theory has driven attention to microecological interaction between the intestinal and reproductive tract microbiota. This review surveys current microecological research on the interplay between endometrial pathologies and alterations, and systematically sorts out the crosstalk mechanism of intestinal and reproductive tract microbiota in occurrence and development of endometrial diseases. Finally, the article explores the key functional microbiota and related regulatory pathways, and looks forward to the potential strategies for the transformation and application from microecological theory to clinical practice.

Key words: uterine diseases, endometrium, gastrointestinal microbiome, genital microbiota

CLC Number:

R711.74

Figures/Tables 2

References 37

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