Multidimensional regulatory mechanism and advances in female reproductive health

doi:10.11958/20253770

Abstract

Abstract:

Female reproductive health depends on the tightly coordinated regulation of ovarian function, embryonic development and the microenvironment at maternal-fetal interface. This review summarizes the molecular mechanism and improvement strategies of ovarian aging, the regulatory mechanism of glucose and lipid metabolism during early embryonic development, and the regulatory mechanism of the immune microenvironment during embryo implantation. Key aspects include: the mechanism of ovarian aging such as telomere shortening, oxidative stress, and mitochondrial dysfunction, along with the potential intervention strategies like rapamycin, exogenous nicotinamide adenine dinucleotide supplementation and small molecule natural medicine. During the early embryonic development, glucose and lipid metabolites such as acetyl CoA participate in regulating gene expression or serve as substrates for histone acetylation to regulate early embryonic development, and the regulation of endometrial receptivity by natural killer cells and T cells during embryo implantation. A deep understanding of the interaction among these regulatory mechanisms is of great significance for developing targeted therapy strategies and maintaining female reproductive health.

Key words: ovary, aging, endometrium, embryonic development, metabolism, immunomodulation

CLC Number:

R715

References 34

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