Abstract: Objective To review the efficacy of α1-blocker in the treatment of urinary calculi post extracorporeal shock wave lithotripsy (ESWL). Methods Key words include Urinary calculi, Alpha-blocker, Randomized clinical trail, Ex⁃ tracorporeal shockwave lithotripsy, et al were searched against databases include Pubmed, Embase, Cochrane Library data⁃ bases and CNKI. All studies that reported effect of α-blockers post ESWL were eligible for the analysis. Data was extracted through quality assessment and data filtering, then were analysed using RevMan 5.0. Results Fourteen randomized clinical trails with a total of 1 464 patients met the inclusion criteria. Pooled analysis showed a better stone clearance and shorter in⁃ terval between stone fragment discharges (RR=1.21, 95%CI:1.10-1.33, P < 0.05) and (SMD= -1.23, 95%CI:-2.09 - -0.36, P < 0.05) respectively after α1-blocker administration. However, evidence is still not convincible that it can reduced the fre⁃ quency of colic episodes (RR= 0.54，95%CI:0.28-1.02, P=0.06). Conclusion α1-blockers facilitates the expulsion of uri⁃ nary calculi shown by a higher expulsion rate, a shorter expulsion interval during treatment. Adjunctive therapy with α1- blockers after ESWL is effective in the treatment of urinary calculi.

Key words: urinary calculi, adrenergic alpha-antagonists, lithotripsy, Meta-analysis