Abstract: ABSTRACT Objective This study was performed to investigate the significance of APACHEⅡ and IL-6 in patients with traumatic hemorrhagic shock by limited fluids resuscitation, Method 106 eligible patients with traumatic hemorrhagic shock were randomly divided into two groups and the healthy control group (n=20). The group of conventional liquid (n=53), Anohter group of limited fluids resuscitation (n=53). The blood samples were taken for lactate, IL-6, and IL-10 measurements. The Acute physiology and chronic health evaluation(APACHEⅡ) were calculated; complications and final clinical outcomes were monitored. Result IL-6, IL-10 in two groups were significantly higher than healthy control groups（p<0.01）.IL-6 in the group of limited fluids resuscitation were significantly lower than the group of conventional liquid （p<0.05）. IL-6 in the group of the non-survival group were higher than those in the group of survival group（p<0.01）.There were no obvious significances in IL-10 between two group（p>0.05）.There were obvious significances in complicationsand mortality（p<0.05）. Conclusion Limited fluids resuscitation can reduce the levels of IL-6, improve the crue rate, lower the daeth rate. Early test of IL-6 and calculated APACHEⅡscores in paitients with traumatic hemorrhagic shock can be used to evaluate the state of illness and prognosis

Key words: Trauma, Shock, Fluids resuscitation, Limited, APACHEⅡ, Interleukin-6, Prognosis