Abstract: to discuss the relationship between albuminuria and carotid artery intima-media thickness (IMT) in type 2 diabetes mellitus.Methods: 146 type 2 diabetes mellitus (T2DM) patients with 24-hour urine microalbumin detection,who based on the results were divided into normal albuminuria group (86 cases) and abnormal albuminuria group (60 cases) (including micro - albuminuria(MAU) group and macroalbuminuria group) .Two groups of patients were carried out on various biochemical indices and carotid artery intima-media thickness (IMT) detection, and two sets of data were analyzed by the single factor, multi-factor logistic regression analysis.Further compare the difference of carotid IMT among the three groups of normal urine, microalbuminuria and macroalbuminuria by variance analysis. Results: ①Single-factor logistic regression analysis showed that duration, the incidence of retinopathy, triglyceride (TG), carotid artery intima-media thickness (IMT) and serum creatinine (Cr) were the risk factors of albuminuria; ②multi-factors logistic regression showed longer duration, higher triglycerides, carotid artery intima-media thickness thickening, increased serum creatinine in patients with type 2 diabetes were the independent risk factors of albuminuria.(the OR values were 1.105,1.528,12.781,1.029respectively).③variance analysis showed: Among the three groups including normal albuminuria group, microalbuminuria group, macroalbuminuria, the difference of carotid artery IMT was statistically significant (P = 0.000), while there were no statistically significant difference between the groups of microalbuminuria and macroalbuminuria (P = 0.805). Conclusion: In patients with type 2 diabetes, carotid artery IMT is an independent risk factor of albuminuria(OR = 12.871), while the severity of diabetic kidney disease and carotid IMT was no significant correlation (P = 0.805).

Key words: type 2 diabetes mellitus, intima-media thickness, diabetic nephropathy, microalbuminuria, albuminuria