Abstract: Objective：To investigate the effect of tirofiban on inflammation f actors in pigs with myocardial infarction reperfusion . Methods：19 Chinese mini pigs were randomized into control group （n=10）and tirofiban-treating group（n=9）. Acute myocardial infarction was induced by method of PTCA. All the successful models accepted DE-MSCT examinations at 1 hour, 24 hours, 48 hours, and 72 hours after reperfusion. All pigs was taken blood at seven different points: 30min before AMI, 30min after AMI, 10min, 2h, 24h, 48h, 72h after reperfusion. The serum levels of IL-6, IL-10, HIF-1αwere measured by enzyme linked immunosorbent assay(ELISA). Result ：（1）The infarct myocardium volume percent was significantly reduced in tirofiban-treating group compared with control group at 24h, 48 and 72h after reperfusion; while the no-reflow volume percent was significantly reduced in tirofiban-treating group compared with control group from 1h to 72h after reperfusion. （2）In tirofiban-treating group, the levels of serum IL-6 were significantly lower than those in control group(p<0.05)，while the levels of serum IL-10 were higher than those in control group(p<0.05).（3） There were no statistical differences between the two groups(p>0.05).Conclusion：Inflammation reaction occurs in ischemic myocardium after AMI and reperfusion ; tirofiban is effective in anti-inflammation, reducing the progress of myocardial necrosis.

Key words: acute myocardial infarction, infarction reperfusion, no-reflow, inflammation factors, R5 glycoproteinⅡb/Ⅲa inhibitor/tirofiban