Abstract: ABSTRACT: Objective By comparison of the changes of sBAP, sCTX, uCTX bone specific biochemical markers and BMD in 52 bone fracture patients and 89 non-fracture patient with type 2 diabetes to explore the mechanism of bone fracture and biochemical markers for prediction of fracture value in type 2 diabetes patients. Methods Dual-energy X-ray absorption metry was used to measure BMD of lumbar spine (L2-4) and the trochanter (Troch), intertrochanteric (Ward's), femoral neck (Neck) of left hip bones ; ELASA enzyme-linked immunosorbent assay shares biochemical markers sBAP, sCTX, uCTX. Results Age, BMI, HbAc1, BMD have no significant difference between fractures and non-fracture patients with type 2 diabetes mellitus； sBAP(31.6±8.0 vs 38.8±6.3) of the bone specific biochemical markers was lower in fracture group than non-fracture group ,howere, sCTX( 9.8±2.5 vs 8.6±1.7), uCTX (35.2±8.2 vs 32.4±7.6 )as the sign of bone resorption have no differentiation between the two groups Conclusion :In fracture patients of type 2 diabetes, the activity of osteoblasts decrease, but osteoclast activity and bone mineral density don’t significantly change. The bone turnover ratio decrease in fracture patients than non-fracture patients of type 2 diabetes. Bone biochemical markers possibly be the early indicators of fracture of type 2 diabetes.

Key words: Diabetes Mellitus, Type 2, Bone Density, Bone and Bones, Fractures, Bone, Alkaline Phosphatase