Abstract: Abstract Objective: To explore the risk factors for the severity of angiographic peripheral arterial disease (PAD) in patients with type 2 diabetes (T2DM). Methods: Four hundred and fifty-five hospitalized T2DM patients were divided into four groups according to color Doppler ultrasound of lower limb, including 109 patients without stenosis (control group), 113 patients with stenosis<30% (mild stenosis group), 118 patients with 30%≤stenosis<70% (moderate stenosis group) and 115 patients with stenosis>70% (severe stenosis group). The risk factors were analysed in subjects of groups. Results: There were significantly higher values of age, course of disease, body mass index (BMI), waist circumference (WC), waist-hip ratio (WHR), waist-height ratio (WHtR), triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL-C), systolic blood pressure (SBP) and glycosylated hemoglobin (HbA1c) in patients of severe stenosis group than those of other groups (P<0.01 or P<0.05). The level of high-density lipoprotein (HDL-C) was lower in patients of moderate stenosis group and severe stenosis group than that of mild stenosis group and control group (P<0.01 or P<0.05). There was a positive correlation between peripheral arterial diseases of lower limb and WHtR, HbA1c, course of disease, age,LDL-C,WC and SBP (P<0.01), but a negative correlation between peripheral arterial diseases of lower limb and HDL-C. Logistic regression analysis showed that values of WHtR, HbA1c and LDL-C were independent risk factors for the severity of angiographic peripheral arterial disease (P<0.01 or P<0.05). The increased level of HDL-C was the protective factor for the arterial diseases of lower limb (P<0.05). Conclusion: WHtR might be an easy and efficient anthropometric index for prognosis of PAD in patients with T2DM.

Key words: diabetes mellitus, type 2diabetic angiopathieslower extremityultrasonography, doppler, colorlipidsbody weights and measuresLogistic modelswaist to height ratio, 彩色