Abstract: Abstract Objective:To investigate the effect of the levels of serum Ang-1 and Ang-2 in aSAH. Methods: We carried out a free aSAH screening in Tianjin. Serum samples were collected as follows: 40 from normal subjects, 31 from patients with aSAH . All the patients were diagnosed by CT and 3D-DSA. Serum levels of Ang1, Ang2 and Tie-2 were tested and compared by enzymelinked immunosorbent assay (ELISA). Results: The levels of serum Ang-1 (t=-8.858, P=0.000), Ang-2 (t=-2.371, P=0.022), SBP (t=-8.844, P=0.000) and DBP (t=-5.316, P=0.000) of aSAH patients had significant higher levels , when compared with healthy subjects. The levels of serum Ang-1,Ang-2 and SBP in the patients of Hunt-Hess I～III were significantly lower than them of Hunt-Hess IV～V (Z=-3.928, P=0.000; Z=-3.657, P=0.000；Z=-2.127, P=0.034). Conclusions: These results suggest that serum Ang1 and Ang2 levels are promising clinically informative biomarkers of disease severity in aSAH.

Key words: angiopoietins, human intracranial aneurysms, aSAH , Hunt-Hess, Hypertension, serum, ELISA