Abstract: Objective To investigate the relation of cellular immunological and humoral immunological indexs of the different iodine intake GD cases . Methods The clinical diagnosis GD cases were undertaked thyroid fine needle Cytology examination. Patients in GD group are divided into GD groupⅠand GD groupⅡ based on urinary iodine level. Detect the blood levels of FT3,FT4,TSH,TGAb,TPOAb,TRAb,TNF-α. Analyze the difference and dependablity of cellular immunological indexs and humoral immunological indexs of the different iodine intake GD cases .Results The positive rates of TGAb, TPOAb GDⅠgroup were higher than GDⅡgroup (P <0.05); The positive rates of TRAb GDⅠgroup were higher than GDⅡgroup (P ＞0.05); the TNF-α level in GDⅠgroup were higher than GD Ⅱ group, but the difference was not statistically significant (P <0.05). It was demonstrated by correlated analysis that FT3 was linear positive correlation with FT4、TRAb、TPOAb.，TNF-α was linear positive correlation with TRAb and TPOAb. Conclusion Iodine is important to development of Graves disease，it should be limited in patients with iodine excess.

Key words: 　Graves disease, urinary iodine, Thyroid auto-antibody, tumor necrosis factor