Abstract: Abstract Objective: Retrospectively study patients with preeclampsia and with gestational hypertension（GH） who delivered at term, the association of retinopathy with various clinical and laboratory manifestations and fetal birth weight was evaluated. Methods: Medical records of 60 patients with preeclampsia and 65 patients with GH who delivered at term were reviewed. Parameters analyzed were retinopathy, systolic and diastolic blood pressure (BP), fetal birth weight, and various biochemical parameters. Multivariable linear regression was used for statistical analysis. P＜0.05 was considered significant. Results: Severity of retinopathy was found to be inversely related to fetal birth weight (P＜0.05) and positively related to serum uric acid level (P＜0.05) in the preeclampsia group. All other variables in the preeclampsia group including systolic BP (mean, 166.4mmHg; P＞0.05) and diastolic BP (mean, 103.5mmHg; P＞0.05) were found to have no significant association with retinopathy. In the GH group, none of the parameters analyzed were significantly associated with ocular changes. Conclusions: The severity of retinopathy in preeclampsia is directly related to the level of placental insufficiency and intrauterine growth retardation. The severity of retinopathy might be independent of systemic BP.

Key words: Preeclampsia, Retinopathy, intrauterine growth retardation, Blood pressure, uric acid