Abstract: Abstract Objective To investigate the principle of diagnosis, therapy and the impact factors of prognosis in traumatic brain injuries (TBI) associated with limbs fractures. Methods 59 TBI cases associated with limbs fractures during 2005 and 2008 in our hospital were retrospectively analyzed. The characteristics of these patients were summarized including their injury mechanisms, brain injury types, clinical characteristics, diagnostic methods, treatment measurements and prognosis. Fish exact test was used to assay the discrepancy in the prognosis of the TBI cases in different Glasgow coma scale (GCS) scores. Results According to the GCS scores, the TBI cases were divided into 3 different groups with 39 mild, 7 moderate and 13 sever ones respectively. The Glasgow outcome scale (GOS) was evaluated to reveal 3 died, 4 sustained in vegetative state, 8 suffered from severe disability , 12 suffered from moderate disability, 32 survived well. There was a straight line correlationship between the admitting GCS scores and the discharging GOS ones. Based on the GCS scores, the prognosis of the different types of TBI cases is different. Conclusion The TBI is a pivotal impacting factor on the prognosis of the patients of TBI associated with limbs fractures. However, it should be emphasized to pay special attention to the diagnosis and treatment of limbs fractures, especially the big bone fractures, when the brain injury is treated actively, which is also very important in reducing the mobility and mortality of this kind of injuries

Key words: Traumatic Brain Injury, Limb Fractures, Management, Prognosis.