Abstract: Abstract Objective:To evaluate the effect of therapy that Paroxetine to post-stroke anxiety（PSA）.Methods:Ninety-four patients with PSA were received the therapy of Paroxetine or Lorazepam at random.The clinical conditions were reviewed by NIHSS and HAMA scale until 8 weeks after beginning of the therapy .Results:By the end of observe period,the scores of NIHSS and HAMA in two group were significantly decreased（P<0.01）,but the scores of NIHSS and HAMA in Paroxetine group were more decreased than those in Lorazepam group（P<0.01）. Conclusion:To treat the PSA,the therapy of Paroxetine has more obvious effects than Lorazepam.

Key words: KeyWordsstroke, Paroxetine, anxiety