Abstract: Abstract: Objective To observe the effects of pulmonary rehabilitation (PR) on depression and anxiety at different stages of chronic obstructive pulmonary disease (COPD) patients. Methods Ninety-seven COPD patients hospitalized in Department of Respiratory Intensive Care Unit, Tianjin Chest Hospital, were randomly divided into two groups: control group (n=39) and acute exacerbation COPD (AECOPD) group (n=58). Patients in both groups were assessed for baseline date when symptoms were improved from acute phase (T1). Then patients in control group were received pharmaco- therapy and rehabilitation publicity without PR. When symptoms was relieved and stable (T2), patients were given 12-week PR (T3). The Beck depression inventory (BDI) scores and State- Trait Anxiety Inventory (STAI) scores were observed in both groups respectively. Results There were no statistics differences in baseline data in both groups (P＞0.05). In control group, the BDI score was significantly lower at T3 than that of T1 and T2 (F=5.309, P＜0.05). But there was no significant difference in BDI between T1 and T2 (P＞0.05). Similarly in AECOPD group, the BDI score was significantly lower at T2 than that of T1 (t=3.612, P＜0.05). At T1, there was no significant difference in BDI score between both groups (P＞0.05). At T2 the BDI score was significantly lower in AECOPD group than that of control group, and also which was lower than that of T3 of control group (P＜0.05). In control group, the STAI score was significantly lower at T3 than that of T1 and T2 (F=9.852, P＜0.05), but there was no significant difference in STAI between T1 and T2 (P＞0.05). The STAI score was significantly lower in T2 than that of T1 in AECOPD group (t=5.091, P＜0.05). There was no significant difference in STAI score at T1 between two groups (P＞0.05). There was significantly lower STAI score at T2 in AECOPD group than that of control group (P＜0.05), while there was no significant difference in STAI score at T3 between two groups (P＞0.05). Conclusion Pulmonary rehabilitation at early stage may reduce the degree of depression and anxiety in AECOPD patients.

Key words: pulmonary disease, chronic obstructive, depression, anxiety, exacerbation, pulmonary rehabilitation