Abstract: 【Abstract】Objective To investigate the effect of sevoflurane-remifentanil anesthesia on spontaneous ventilation recovery. Methods Four hundreds ASAⅠorⅡpatients aged 18-63 yr，weighing 52~80 kg scheduled for elective surgery were randomly divided into 2 groups(n=200 each): sevoflurane group(Ⅰ) and sevoflurane-remifentanil group(Ⅱ).Anesthesia was induced with fentanyl,propofol and vecuronium.The patients were mechanically ventilated after tracheal intubation. Anesthesia were maintained with 1MAC sevoflurane and intermittent iv boluses of fentanyl in groupⅠand 1MAC sevoflurane and iv infusion remifentanil 0.1~0.2μg.kg-1.min-1 in group Ⅱ.All patients recieved in bolus of vecuronium when spontaneous respiratory was reversed.The times of spontaneous ventilation recovery per patient,the amount of vecuronium,the cases of TOF≥0.9 at immediately point of opertion ending and the duration of tracheal extubation were recorded.Results The 189 cases in groupⅠand 187 cases in group Ⅱwere taken into statistical analysis .There were a higher incidence of spontaneous ventilation recovery and more amount of vecuronium in groupⅠthan that in group Ⅱ（p<0.05）; the cases of TOF≥0.9 at immediately point of opertion ending in groupⅠ(48 cases) were significantly less than that in group Ⅱ(163cases)（p<0.05）; meanwhile,the duration of tracheal extubation was shorter in group Ⅱthan that in groupⅠ（p<0.05）.Conclusion Sevoflurane-remifentanil anesthesia caused so strongly respiratory depression that less amount of vecuronium was required during perioperative.

Key words: Remifentanil, Sevoflurane, General anesthsia, Spontaneous ventilation