Abstract: abstract Objective: To evaluate the effect of probucol and atorvastatin combined medication on blood levels of liquids and Lp-PLA2 in patients with acute coronary syndrome(ACS)．Method: A total of 94 patients with acute coronary syndrome who had been diognosised by CAG were randomly divided into two groups: single medication group(n=48)，the patients were taken atorvastatin 20 mg/d；and combined medication group(n=46)，the patients were taken atorvastatin 20 mg/d with probucol 500 mg/d.The plasma levels of Lp-PLA2 ，total cholesterol(TC)，triglyceride(TG)，low density lipoprotein-cholesterol (LDL-C) were measured in both groups before and 6-8 weeks after the medication.Then the results were compared and analysed .Resultes: There was no significant diffierence in the levels of TC、TG、LDL-C、HDL-C and Lp-PLA2 before treatment between the two roups(P>0．05)．The values of TC、TG、LDL-C and Lp-PLA2 were significantly decreased after the treatment in both two groups(P<0．01).Compared with single medication group,the value of TC, LDL-C, Lp-PLA2 were more significantly decreased in combined medication group (P0．05)．The values of HDL-C was increased after the treatment in the single medication group(P<0．O1),while decreased in the combined medication group(P<0．O1). Conclusion: The values of TC、LDL-C and Lp-PLA2 can both decrease by single atorvastatin medication or probucol and atorvastatin combined medication but more significantly by combined medication . Combined treatment played an important role in stabilizing the plaques and antiatherosclorosis in ACS patients.

Key words: phospholipases A2, probucol, acute coronary syndrome, atorvastatin, lipoproteins