Abstract: Objective: To investigate the impact of extracorporeal membrane oxygenation(ECMO) assisted beating heart coronary artery bypass graft(CABG) on inflammatory factors, and compare it with conventional coronary artery bypass graft (CCABG) and off-pump coronary artery bypass graft(OPCABG). Method: 45 patients with coronary artery disease undergo CABG were divided into three groups: CCABG group, ECMO assisted CABG group and OPCABG group, for each group 15 patients. The blood samples were collected from peripheral vein at the moment preanesthesia(T1) , 10 min after pump or ECMO starting 10 min(T2) , pump or ECMO stopped or surgery finished moment(T3) , 4th hour after surgery(T4) and 24th hour after surgery(T5) . Centrifuged blood samples for plasma. Observe the change patterns of inflammatory cytokines tumor necrosis factor-α(TNF-α), interleukin-6(IL-6) and interleukin-8 (IL-8) measured by enzyme-linked immune sorbent assay(ELISA). Result: The patient ages were significantly higher in ECMO assisted group than the other two groups(P<0.05). There was significant plasma level increase of inflammatory factors since pump or ECMO starting compared with preanesthesia (P < 0.05), and they had reached peak before 4th hour after surgery, kept a high level even at 24th hour after surgery. At the moment after surgery, the plasma level of TNF-α，IL-6 and IL-8 was obviously lower in both ECMO assisted group and CCABG group(P<0.05), but after 4h there was no significant difference among three groups(P>0.05). Conclusion: Though there is no significant superiority compared ECMO assisted beating heart coronary artery bypass graft with other surgery methods, the patient ages are obviously higher in ECMO assisted group, and it may be a new surgery pathway for ageing patients.

Key words: Extracorporeal membrane oxygenation, Inflammatory factors, c Coronary artery bypass graft, c Coronary artery disease, Mini bypass