Abstract: 【Abstract】 Objective To evaluate the effects of dexmedetomidine infusion on sedation of patients undergoing awake fibreoptic nasal intubation. Methods Thirty ASAⅠ or Ⅱpatients aged 21～72 yr weighing 46～85kg scheduled for elective oral surgery were randomly allocated into 2 groups ( n=15 each): dexmedetomidine group(group D)and fentanyl group(group F). Patients in group D received dexmedetomidine 1μg/kg infusion. Patients in group F received fentanyl 1μg/kg infusion. The fiberoptic nasal intubation time was recorded. The changes of HR, BP, SPO2, BIS, sedation (the Ramsay score), satisfaction in the two group at T1 (before drug administration), T2 (after drug administration) and T3 (intubation) were observed. Results Compared with T1, HR obviously decreased at T2、T3 in group D, while the Ramsay score is increased（P <0.05）. Compared with group F,the change of SBP at T3 is small（P <0.05）. There were no significantly differences of BIS, SPO2 at T1 , T2 , T3 （P >0.05）.The patient’s tolerance and satisfaction scores of group D were better than Group F（P <0.05）. Conclusion Combination of dexmedetomidine loading with topic anaesthesia can allow better sedation, stable haemodynamic status, absence of respiratory depression in awake fibreoptic nasal intubation.

Key words: Dexmedetomidine, awake, fibreoptic nasal intubation.