Abstract: Abstract Objective: To investigate the changes of ratio of serum IL-8/IL-10 after percutaneous coronary intervention (PCI) and the related factors. Methods: A total of 103 patients undergoing coronary angiography (CAG) were recruited, who were divided into SA1 group (patients with stable angina only undergoing CAG, n=31), SA2 group (patients with stable angina undergoing PCI, n=34), and UA group (patients with unstable angina undergoing PCI, n=38). Blood samples were taken in order to evaluate serum concentrations of high-sensitivity C-reactive protein (hs-CRP), interleukin (IL)-8 and IL-10 just before PCI and 24 h after the procedure. Results: (1) In both SA2 and UA group, the ratio of IL-8/IL-10 after PCI was higher than that before PCI (P < 0.05, P < 0.01). (2) After PCI, the ratio of IL-8/IL-10 in the UA group was higher than that in both SA1 and SA2 group (P < 0.001). (3) The ratio of IL-8/IL-10 before PCI and the situation of unstable angina correlated with the ratio of IL-8/IL-10 after PCI. Conclusion: There exists inflammatory cytokine imbalance after PCI, which triggers a systemic inflammatory response. Moreover, this response is more obvious in patients with inflammatory cytokine imbalance before PCI and unstable angina.

Key words: percutaneous coronary intervention, interleukin-8, interleukin-10