Abstract: Objective: To investigate the changes of serum lipids in patients with systemic lupus erythematosus and the correlation between this change and the activity of SLE and renal involvement.Methods: Blood lipid levels were analyzed by routine chemistry. Disease activity was estimated using the Systemic lupus Erythematosis Disease Activity Index (SLEDAI). Anti-dsDNA antibody was measured by indirect immunofluorescence (IIF) and renal involvement in SLE was monitored. Results：The serum level of TG was higher in SLE group than control group, and the serum level of HDL was significantly lower in SLE group than control group, the difference was significant（P<0.01）. The level of LDL in the two groups was not significant. The serum level of TG was higher significantly in active SLE group than inactive SLE group（P<0.01）, and the level of HDL was lower significantly in active SLE group than inactive SLE group（P<0.05）. The level of LDL in the two groups was not significant. TG was positively related to the SLEDAI score (r=0.53, P<0.05), and HDL was negatively related to SLEDAI score (r=-0.62, P<0.01). The level of TG was significantly elevated in positive anti-dsDNA group than negative anti-dsDNA group (P<0.01). The level of HDL was significantly lower in positive anti-dsDNA group than negative anti-dsDNA group (P<0.05). The level of LDL in the two groups was not significant.The level of TG was higher in SLE patients with renal involvement than without renal involvement, the level of HDL was lower in SLE patients with renal involvement than without renal involvement (P<0.01). The level of LDL in the two groups was not significant. Conclusion Dyslipoproteinemia with high levels of TG and low levels of HDL correlates with disease activity in patients with SLE. Also dyslipoproteinemia was related to renal manifestations in SLE, and thus it maybe serve as markers of more severe disease.

Key words: Systemic lupus erythematosus, Dyslipidemia, renal involvement