Abstract: Abstract Objective  To investigate chronic sinusitis impact on chronic obstructive pulmonary disease (COPD) patients quality of life and the influence of acute aggravating. Methods   For the 101 patients who met the inclusion criteria in hospital history collection, In the next early morning 6h extraction fasting venous blood samples 20ml,determination of erythrocyte sedimentation rate、 C reactive protein,、blood coagulation items;then we calculated the CAT score, reviewed the acute exacerbations of 1 year before admission hospitalization, recorded the time of hospitalization of each patient enrolled in the study .The patients were divided into two groups : simple COPD group and group of COPD combined with chronic rhinosinusitis, according to the results of paranasal sinus CT scans.Then the data were analyzed through SPSS software(Version 17.0).Results   Sinus CT scan examination showed 101 COPD patients with chronic rhinosinusitis incidence was 64.1%(62/101). 62.9% (39 / 62)of 62 patients with chronic sinusitis had nasal symptoms, while 37.1%（23/62）patients without any nasal symptoms. Maxillary sinus was the most frequently involved 93.55%（58/62）, followed by the ethmoid sinus30.65%（19/62）. CAT scores and the acute exacerbation frequency increased more significantly in the group of combined with chronic rhinosinusitis, than the group of only COPD ( P < 0.05 ), but the two groups when compared to the ESR and CRP, FIB and length of hospital stay indifference, compared with no difference in the occurrence of different classification of lung function in COPD patients with chronic sinusitis.. Conclusion  Chronic rhinosinusitis were the most common upper respiratory tract complications of COPD,and it influents the quality of life and acute exacerbation of the patient. Unfortunately the clinical diagnosis rate is too low,which calls for more attentions.

Key words: chronic obstructive pulmonary disease, chronic sinusitis, blood sedimentation, C-reactive protein, fibrinogen, CAT score