Abstract:

[Abstract]   Objective   To study clinical value and significance of thyroid receptor stimulating antibody (TSAb) and
thyroid stimulating- blocking antibody (TSBAb) on diagnosis and treatment for children with Graves’ disease (GD) and
Hashimoto’ s thyroiditis (HT).   Methods   Eighty-eight children with autoimmune thyroid disease (AITD) and treatment time less six months were divided into GD group (n=55) and HT group (n=33). Thirty-eight healthy children were used as control (Normal group). Human serum TSAb ELISA kit and human TSBAb ELISA kit were used to detect the serum TSAb and serum TSBAb in three groups. The serum levels of TSAb and TSBAb were compared between three groups. The correlation between TSAb and TSBAb, TSAb/TSBAb and free triiodothyronine three (FT3), free thyroxine (FT4), ultra sensitive thyroid stimulating hormone (TSH) were analyzed.   Results   The serum level of TSAb was significantly higher in GD group than that of HT group and Normal group (P<0.05). The serum level of TSBAb was significantly higher in HT group than that of Normal group (P<0.05). There was no significant correlation between serum TSAb and serum TSBAb (P>0.05). There were no significant correlation between serum TSAb, TSBAb and FT3, FT4, TSH (P>0.05).   Conclusion   TSAb and TSBAb are related to the pathogenesis of GD and HT in children. TSAb and TSBAb have an important clinical value in the diagnosis and treatment for children with GD and HT.

Key words: Graves disease, Hashimoto disease, TSAb, TSBAb, autoimmune thyroid disease, child