Abstract: Objective Observed total flavone from Litchi chinensis Sonn on liver function improvement and collagen Ⅰ, 3 and p16 in bile duct ligation liver fibrosis (bile duct ligation, BDL) rats.Methods The rats model is the rats after ligation of the common bile duct，forty SD rats was randomized into the common bile duct ligation (BDL group), Litchi flavonoids group (TFL group), silibinin group (SIL group),to the control group (SO group) as a negative control. After four weeks,serum detection of serum superoxide dismutase(SOD),alanine aminotransferase(ALT),aspartate aminotransferase (AST), direct bilirubin (BILD2), total bilirubin (BILT2) , creatinine (CREJ2), blood urea nitrogen (UREAL) were measured, and the pathological observation was also performed on legt liver lobes with HE, Masson staining, western blot were measured in liver tissue PC3, PC Ⅰ, p16 expression.Results The serum SOD in TFL was significantly higher than that in the BDL group (P <0.05), The serum ALT, AST, BILD2, BILT2 levels were significantly lower than that in the BDL group(P <0.05), TFL can significantly improve the degree of hepatic fibrosis in rats (P <0.05 ), TFL can inhibit p16, PC3, PC Ⅰprotein expression (P <0.05).Conclusion TFL group has a significant improvement in cholestasis and liver fibrosis mitigate, significantly inhibited cholestatic liver fibrosis in rat liver p16, PC3, PC Ⅰ protein.

Key words: flavone from Litchi chinensis Sonn, Cholestatic liver fibrosis, PC3, PC Ⅰ, p16