Abstract: Objective To evaluate the relationship between genetic polymorphism of transforming growth factorβ1 (TGFβ1) and susceptibility of liver cirrhosis after hepatitis B virus infection in Chinese population. Methods CBM, VIP, CNKI, Wanfang technological periodical full-text databases and Pubmed from set up to July, 2013 were electronically searched to identify case-control studies on the relationship between genetic polymorphism of TGF β1 promoter 509 site, codon 869 site and liver cirrhosis after hepatitis B virus infection. The data were quantitatively analyzed by RevMan 5.1 software after assessing the quality of included studies. Results 6 case-control studies were selected for Meta-analysis based on our inclusion and exclusion standards. The results of meta-analysis showed that the pooled OR value for liver cirrhosis among Chinese patients after hepatitis B virus infection with T allele of TGFβ1 gene at promoter 509 was 1.02 (95％CI: 0.67~1.54), the pooled OR values for patients with TT and CT genotype were 0.80 (95％CI: 0.36~1.78); Patients with C allele of TGFβ1 gene at codon 869 was 1.05 (95％CI: 0.69~1.62), the pooled OR values for patients with CC and CT genotype were 0.98 (95％CI: 0.48~2.00). No significant publication bias was found. Conclusion The genetic polymorphism of TGFβ1 at promoter 509 and codon 869 shows no association with susceptibility of liver cirrhosis after hepatitis B virus infection in Chinese population.

Key words: liver cirrhosis, genetic polymorphism of transforming growth factor β1, meta-analysis