Abstract:

Abstract： Objective To observe curative effect of the rat nerve growth factor (NGF) treatment on anterior ischemic op⁃
tic neuropathy（AION） . Methods Patients with AION (n=78) were randomly divided into mouse NGF treatment group
(treatment group): 39 cases (39 eyes) and conventional treatment group (control group): 37 cases (37 eyes). Patients in control
group were given Actovegin 1.2 g intravenously, once a day while patients in treatment group were given 18 μg mouse NGF
once a day. Milton insurable were given orally at 0.5 mg, 3 times per day at both groups. Dexamethasone of 3 mg were given
retrobulbarly once a day upon onset of symptoms and the extend of edema for 3 to 5 days. Rat nerve growth factor were given
for consecutive14 days as a period of treatment, and the curative effect was observed after 28 days of treatment. Results In
the treatment group: treatments were obviously effective in 28 eyes (71.79%), effective in 7 eyes (17.95%) and ineffective in
4 eyes (10.26%), so the total effective rate was 89.74%; In control group: treatments were obviously effective in 11 eyes
(29.73%), effective in 15 eyes (40.54%) and ineffective in 11 eyes (29.73%), so the total effective rate was 70.27%. Curative
effects in these 2 groups were of statistical significance (Z=3.552, P＜0.05). Vision acuity and average light sensitivity in vi⁃
sual field are better in treatment group than those control group (P＜0.05). Conclusion Mouse NGF is effective in the treat⁃
ment of AION and can improve vision acuity and visual field, therefore is worth promoting

Key words: ischemia, optic nerve diseases, nerve growth factors, muridae, injectio, therapy