Abstract: Objective To discuss and observe the clinical effect of intervertebral pedicle internal fixation and debride⁃ ment combined with bone graft through posterior approach/trans-intervertebral space approach on the treatment of uni/multisegmental lumbosacral vertebral tuberculosis (TB). Methods A cohort of 37 patients, with single or multiple segmental ver⁃ tebral destruction due to TB, were treated by trans-intervertebral debridement, posterior pedicle screw system internal fixa⁃ tion and intervertebral bone graft. All patients underwent X-ray，CT and MRI examination to observe the combination treat⁃ ment effect. Results Most patients (n=34) enjoyed primary healing, in which include only 4 cases that presented symptom of nerve root stretch injury during operation but all recovered after 3 months. Other 3 patients underwent secondary healing due to sinus but two were rectifying with anti-TB therapy and wound dressing. The other 1 case suffered from sinus tract was healed through second debridement and rectifying therapy. X-ray, CT and MR at 6 months after operation indicated that all patients present great graft osseous fusion, good recovering of height of vertebral body without kyphosis deformity nor internal fixation loosening nor screw breakage. Conclusion Intervertebral pedicle internal fixation and debridement combined with bone graft through posterior approach/trans-intervertebral space approach is with minimum invasion but good graft fusion ef⁃ fects,harderfixationandsatisfactoryclinicaleffectsinthetreatmentofuni/multi-segmentallumbosacralvertebraltuberculosis.

Key words: postoperative complications, intervertebral space approach, lumbosacral tuberculosis, prognosis