Abstract: Abstract：Objective To investigate the clinic value of enhanced CT-guided percutaneously transthoracic lung biopsy. Methods A total of 423 patients who underwent CT-guided percutaneously transthoracic lung biopsy were retrospectively analyzed. The percentage of specimen are satisfactory，the rate of sample with pathological findings，the number of cases with complications，theaveragegoesofunsuccessfulbiopsyandthetimesofchangingpuncturepointwerecomparedbetweentheenhanced CT group and the plain CT group. Results Compare parameters in patients whose procedure were guided with the enhanced CT group and with plain CT group, the average goes of unsuccessful biopsy, the times of changing puncture point in patients, the percentage of specimen that were satisfactory, the rate of sample with positive pathological findings and the rate that complicated with pneumothorax or hemorrhage show statistical significance（. 3.08±1.05 vs 3.75±1.34, 8.52% vs 18.54%,90.13% vs 73.60%, 76.62% vs 63.36%, 15.51% vs 27.53%, 7.76% vs 14.04%, P＜0.05）. Conclusion In patient whose biopsys were guided by enhanced CT, the percentage of samples that are satisfactory is higher, the incidence of complication is fewer and the sample with pathological finding is higher compared to those in patients whose biopsys were guided by plain CT. Therefore, enhanced CTguided percutaneous transthoracic biopsy is more valuable than plane CT.

Key words: tomography, X-ray computed, lung, biopsy, pneumothorax, hemorrhage, enhanced CT, complication