Abstract: Abstract：Objective To evaluate the safety and efficacy of abdominal aorta balloon occlusion in the treatment of perilous placenta previa (PPP) patients with placenta implantation. Methods The literature data were retrieved from the electronic databases of PubMed, Cochrane Library, Web of Science and EMbase. The retrieval time was from the database construction to March 2018. Two reviewers independently screened literature extracted data and evaluated the quality of the included studies according to the inclusion and exclusion criteria. Then, Meta-analysis was performed by RevMan 5.3 software. Results Finally, 6 retrospective cohort studies involving 515 patients (342 cases in balloon group and 173 cases in control group) were included. The results of Meta-analysis showed that the intraoperative blood loss was less in the balloon group than that of the control group (SMD=-0.51, 95%CI:-0.80- -0.23, P=0.000 4), and the hysterectomy rate was lower in the balloon group than that of the control group (OR=0.40, 95%CI: 0.21-0.74, P=0.003). But there were no significant differences in the amount of packed red blood cell transfusion (SMD=-0.23, 95%CI: -0.54 - 0.07, P=0.13) and the length of postoperative hospitalization (SMD=- 0.23, 95%CI: - 0.12-0.58, P=0.20) between the two groups. The associated adverse reactions of abdominal aorta balloon occlusion included hematoma of the puncture point and arterial/vein thrombosis. The above complications were all relieved after conservative treatments. Conclusion The treatment of PPP patients with implantation by abdominal aorta balloon could decrease the amount of bleeding during the operation, reduce the hysterectomy rate, and has no serious related complications. However, the above conclusions still need more high quality and large sample studies to futher verify.

Key words: placenta previa, Meta-analysis, perilous placenta previa, abdominal aorta balloon occlusion