Abstract: Abstract: Objective To investigate the effect of renal brain expression protein (KIBRA) gene rs17070145 polymorphism on cognitive function score and brain functional connection density (FCD), and provide genetic and imaging indices for early identification of Alzheimer’s disease (AD). Methods Healthy Han young people in Tianjin were continuously collected from March 2015 to August 2015. A total of 267 participants with complete behavioral, genetic data and magnetic resonance imaging data, were recruited in this study. The KIBRA C/T alleles were genotyped. Participants were divided into C-allele carrier group (TC＋CC) and TT homozygous carrier group. The Chinese revised Wechsler memory scale and perseverative responses errors percentage in Wisconsin card sorting test were used to assess memory and executive function. After routing preprocessing steps for the resting state, the global FCD value was calculated, and then the differences between genotype groups were compared. Results There was a marginal difference in long term memory between different genotype groups (P=0.05). There were no significant differences in age, sex, education years and perseverative response error percentage between different genotype groups (P＞0.05). Compared to TT homozygous carrier group, the global FCD value in right occipital gyrus was increased in C-allele carrier group (P＜0.05). Conclusion The brain activity in occipital lobe could be affected by KIBRA gene polymorphism in Tianjin Han young people. The increasement of brain function activity in occipital lobe of C allele carriers may be a compensation for the poor performance of long term memory

Key words: polymorphism, single nucleotide, magnetic resonance imaging, KIBRA, functional connectivity