Abstract: Abstract: Objective To investigate the relationship between late gadolinium enhancement (LGE) in magnetic resonance and the slope of dynamic electrocardiogram QTe / RR in hypertrophic cardiomyopathy (HCM). Methods According to the presence of LGE in cardiac magnetic resonance imaging (CMR), 96 patients with HCM who were admitted to our hospital from January 2016 to June 2017 were divided into LGE positive group and LGE negative group. The LGE transmurality of LGE positive group was evaluated by scoring method. All subjects underwent 24 h dynamic echocardiography, and heart rate (HR), QT interval and QTe/RR slope were calculated. The correlation between total LGE score and the slope of QTe/RR in LGE positive group was analyzed. And the relationships between the transmural degree of LGE and the slope of QTe/RR with the prognosis of patients were also analyzed. Results CMR results showed that there were 51 cases of positive LGE (53.13%), 45 cases of negative LGE (46.87%). There were significant differences in left ventricular ejection fraction (LVEF: 0.412 ± 0.092 vs. 0.508 ± 0.083), left ventricular end-diastolic volume [LVEDV (mL): 173.91±43.68 vs. 148.52±31.77] and left ventricular end-diastolic wall thickness [LVPWD (mm): 13.26±2.81 vs. 12.15± 2.37] between LGE positive group and LGE negative group (t=5.301, 3.219 and 2.077, P＜0.05). The QT interval (439.67± 25.82 vs. 411.53±31.66) and QTe/RR slope (0.20±0.05 vs. 0.16±0.03) were significantly longer in LGE positive group than those of LGE negative group (t=4.794 and 4.674, P＜0.05). The total LGE score was 26.37 ± 7.52, which was positively correlated with the slope of QTe/RR in LGE positive group (r=0.742, P＜0.001). The incidence of adverse reactions such as ventricular arrhythmia and sudden cardiac death were significantly higher in LGE positive group than those in LGE negative group (c2=4.107, P＜0.05). The total LGE score and QTe / RR slope were related to ventricular arrhythmia and sudden cardiac death (P＜0.05). Conclusion The LGE degree of HCM patients is significantly correlated with the slope of QTe/ RR. The comprehensive evaluation of the two indicators may be more helpful to predict the prognosis of HCM.

Key words: cardiomyopathy, hypertrophic, electrocardiography, magnetic resonance imaging, gadolinium, 24 h dynamic cardiogram, slope of QTe/RR