Abstract: Objective　To compare the clinical efficacy between lumbar disc herniation treated by spinal endoscope in ambulatory surgery mode and general hospitalization mode during the prevalence of the COVID-19. Methods　The 100 patients with lumbar disc herniation treated by percutaneous endoscopic lumbar discectomy (PELD) with ambulatory surgery mode or general hospitalization mode were analyzed retrospectively. The operation time, blood loss, hospitalization time and hospitalization cost were compared between the two groups. Visual analogue scale (VAS), Oswestry disability index (ODI) and modified MacNab criteria were performed before surgery and 1 month after surgery in the two groups of patients. Results　All the patients completed PELD surgery successfully. The hospitalization time and hospitalization cost were significantly lower in the ambulatory surgery mode than those of the general hospitalization mode (P＜0.05). The VAS and ODI scores were significantly improved after operation compared with those before operation in the two groups (P＜0.05). There were no significant differences in the VAS and ODI scores before and after the operation between the two groups of patients. The excellent and good rates of modified MacNab in the ambulatory surgery mode and general hospitalization mode were 91.7% and 92.0% respectively, and there was no significant difference between them (P＞0.05). Conclusion　During the prevalence of the COVID-19, PELD in ambulatory surgery mode is safe, feasible and effective. It can reduce the hospitalization time and hospitalization cost, which is worthy of popularization and application.