Abstract: MicroRNAs (miRNAs)，a class of endogenous small non-coding RNAs, generally regulate gene expressions
at post-transcriptional level through mRNA degradation or translation inhibition. miRNAs are involved in multiple
physiological or pathological processes. miRNA can regulate the expression of oncogene and tumor suppressor gene to
participate in the development of tumor. Different types or different stages of tumors show distinct miRNA expression
profiles, which imply the potential applications of miRNAs. miR-27a is located at human chromosome 19 and shows
dysregulated expressions in endometrial cancer, ovarian cancer, cervical cancer and many other diseases. In this review, we
summarized the research progress of miR-27a in human gynecological tumors, providing novel insights on the development
of tumor biomarkers or therapeutic agents.

Key words: miR-27a；gynecological tumor, review