Abstract: Objective　To explore the effect of adenomyosis on the clinical outcomes of in vitro fertilization-embryo transfer (IVF-ET) by using propensity score matching (PSM) method. Methods　A total of 740 women underwent IVF-ET were retrospectively analyzed. Among them, there were 134 patients with adenomyosis (adenomyosis group) and 606 patients with infertility due to fallopian tube factors (control group). Based on age, years of infertility, body mass index (BMI) and basic estrogen level, the two groups of patients were matched with 1∶1 propensity score matching (PSM). After matching, there were 96 cases in each of the two groups. The differences in baseline characteristics, fertility outcomes and pregnancy outcomes before and after matching were compared between the two groups. Results　Before and after PSM matching, the dosage of gonadotropin (Gn) was increased, and the daily estradiol (E2) level of human chorionic gonadotropin (HCG) was decreased in the adenomyosis group compared with those of the control group (P＜0.05). In terms of the outcomes of assisted pregnancy, the number of oocytes retrieved, the number of mature oocytes, the number of oocytes normally fertilised, the number of available embryos and the number of frozen embryos were significantly lower in the adenomyosis group than those in the control group (P＜0.05). Conclusion　Adenomyosis is related to the adverse pregnancy outcomes of IVF-ET.

Key words: adenomyosis, fertilization in vitro, embryo transfer, pregnancy outcome, propensity score matching