Abstract: Psoriasis is a common chronic inflammatory skin disease. Its pathogenesis is extremely complex. Abnormal proliferation of keratinocytes (KCs) is one of its important pathological features. In the process of pathopoiesis, many factors can cause keratinocytes proliferation，interacting with each other, thus leading to the recurrence of psoriasis and the fact that it is more difficult to cure. In this paper, we focus on inflammatory cytokines, oxidative stress, microRNA and the antagonism of traditional Chinese medicine on keratinocytes proliferation looking forward to provide reference for further study of pathogenesis and clinical precise treatment of psoriasis.