Research progress on the role of Gal-3 in Alzheimer’s disease

doi:10.11958/20220639

Abstract

Abstract:

Galectin-3 (Gal-3), widely expressed in central nervous system, is a member of the galectin family. Gal-3 can bind a variety of molecules and play a role by regulating downstream signals. Recent advances have suggested that changes in Gal-3 expression in brain tissues, serum and cerebrospinal fluid of patients with Alzheimer's disease (AD) are closely related to the severity of AD. Therefore, GAL-3 is expected to be an important biomarker for the diagnosis and detection of drug efficacy in AD. In this review, we present an updated overview of the current understanding of Gal-3 involvement in AD, which may provide useful references for the clinical diagnosis and treatment of AD in the future.

Key words: Alzheimer disease, Galectin 3, inflammation, amyloid beta-peptides, microglia

CLC Number:

R338.2

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