Research progress on the role of HMGB1 and RAGE in ventilator associated pneumonia

doi:10.11958/20230486

Abstract

Abstract:

The pathogenesis of ventilator associated pneumonia (VAP) is complicated, and inflammatory response plays a key role in the pathological process of VAP. High mobility group protein B1 (HMGB1) and advanced glycation end-product receptor (RAGE) are key mediums for inflammatory response and play an important role in the progression of sepsis. Sepsis is the main outcome and cause of death of VAP. Therefore, HMGB1/RAGE may be used as markers and therapeutic targets for early detection of VAP progression into sepsis. This article reviews the role of HMGB1/RAGE in the development of VAP inflammatory and the progress in its treatment.

Key words: pneumonia, ventilator-associated, HMGB1 protein, receptor for advanced glycation end products, sepsis, inflammation, inhibitors

CLC Number:

R563.1

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