Abstract: Myeloid derived suppressor cells (MDSCs) are immunosuppressor cells that have attracted much attention and play a role in regulating immune response. Recently, accumulating evidence has demonstrated that MDSCs are closely related to the development and prognosis of hepatic cancer. Multiple factors in the microenvironment of hepatic cancer affect the expansion, activation and recruitment of MDSCs, while MDSCs promote tumor growth and metastasis by downregulating antitumor immune response or inducing immune tolerance. The study on effect of MDSCs on immune escape of hepatic cancer will provide new clues for early detection, diagnosis and immunotherapy of hepatic cancer.

Key words: liver neoplasms, myeloid cells, suppressor factors, immunologic, tumor escape, review, microenvironment