Abstract: Abstract：Colorectal cancer is a kind of cancer with both high morbidity and mortality. Chemotherapy is one of the most commonly used treatments in clinic, however toxicity and drug sensitivity to the same chemotherapy regimen are vary greatly in different patients. More and more studies have confirmed that this individual difference is closely related to gene polymorphism. At present, the research of gene polymorphism in targeted therapy of colorectal cancer has been widely accepted, and the research in chemotherapy has become more and more extensive. Combined chemotherapy has significant effect in clinical treatment of colorectal cancer. Therefore, the identification of these gene polymorphisms has important guiding significance for precise chemotherapy and combined chemotherapy of colorectal cancer. This article reviewed the gene polymorphisms associated with chemotherapeutics drugs and regimens commonly used in colorectal cancer, as well as their clinical significances.

Key words:  colorectal neoplasms, polymorphism, single nucleotide, antineoplastic combined chemotherapy protocols, drug-related adverse reactions, review