Tianjin Medical Journal ›› 2019, Vol. 47 ›› Issue (10): 1085-1088.doi: 10.11958/20190460

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Study on the application value of serum tumor abnormal protein combined with urine cytokeratin-19 detection in the early diagnosis of bladder cancer

WU Wan-wen△, LYU Cai, LIU Zhen-xiang, XU Hai-xia, ZHANG Shu-fang   

  1. Urology Surgery, Pathology Department, Central Laboratory, Haikou People’s Hospital (Central South University Xiangya School of Medicine Affiliated to Haikou Hospital), Haikou 570208, China
  • Received:2019-02-20 Revised:2019-07-29 Published:2019-10-15 Online:2019-11-11
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Abstract: Abstract: Objective To investigate the application value of serum tumor abnormal protein (TAP) combined with urine cytokeratin-19 (CK-19) detection in the early diagnosis of bladder cancer. Methods Fifty patients with bladder cancer confirmed by pathology (bladder cancer group) and 45 patients with benign diseases of urinary system (control group) were retrospectively analyzed. The serum levels of TAP and urine CK-19 levels were detected by agglutination method and enzyme linked immunoabsorbent assay in the two groups, respectively. Binary Logistic regression analysis was used to establish a new diagnostic index for TAP and CK-19 combined detection. The ROC curve was drawn to analyze the diagnostic value of TAP and CK-19 separate or combined detection for bladder cancer. The diagnostic efficacy of TAP and CK-19 alone and combined detection was calculated. Results TAP and CK-19 levels were significantly higher in bladder cancer group than those in control group (P<0.01). The area under the ROC curve detected by TAP combined with CK-19 [0.918 (95%CI: 0.864-0.973)] was higher than that by TAP alone [0.876 (95%CI: 0.809-0.944)] and CK-19 alone [0.821 (95%CI: 0.727-0.915)]. The Youden index of the joint diagnosis of the two indicators (0.83) was also higher than the two separate indicators (TAP: 0.61; CK-19: 0.64), and the sensitivity (90.00%) and specificity (93.33%) of the combined diagnosis of the two indicators were greater than the single indicator (TAP: 70.00%/91.11%; CK-19: 84.00%/80.00%). Conclusion Combined detection of TAP and CK-19 can improve the diagnostic value and efficacy of single indicator detection and can be used as a new indicator for the early diagnosis of bladder cancer.

Key words: urinary bladder neoplasms, early detection of cancer, ROC curve, tumor abnormal protein, cytokeratin-19

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