Abstract: Objective To investigate the effects of lanthanum carbonate chewable tablets combined with calcium acetate tablets on the serum calcium correction concentration, phosphorus concentration, vascular calcification and parathyroid gland function in maintenance hemodialysis (MHD). Methods Ninety patients with MHD admitted to our hospital from September 2017 to September 2018 were selected as subjects. According to the random number table method, 90 patients with MHD were divided into control group (45 cases) and study group (45 cases). The patients in the control group were treated with calcium acetate tablets and the patients in the study group were treated with lanthanum carbonate chewable tablets on the basis of the control group. Both groups were treated continuously for 12 weeks. The clinical efficacy was evaluated. The serum calcium correction concentration, phosphorus concentration, coronary artery calcification score (CACS) and serum parathyroid hormone (PTH) concentration were compared before and after treatment between the two groups. Results After treatment, the total effective rate was significantly higher in the study group than that of the control group (93.33% vs. 75.56%, P＜0.05). After treatment, the serum calcium correction concentration was significantly higher than that before treatment in both groups, and the serum phosphorus concentration and calcium-phosphorus product were significantly lower than those before treatment (P＜0.05). After treatment, the serum calcium correction concentration, the serum phosphorus concentration and calcium-phosphorus product were significantly lower in the study group than those in the control group (P＜0.05). After treatment, the levels of CACS and PTH were significantly lower than those before treatment in both groups (P＜0.05). The concentration of CACS and serum PTH was significantly lower in the study groupthan that in the control group (P＜0.05). There was no significant difference in the incidence of adverse drug reactions between the two groups (P＞0.05). Conclusion Lanthanum carbonate chewable tablets combined with calcium acetate tablets can effectively correct the abnormal metabolisms of calcium and phosphorus in MHD patients, delay the progress of vascular calcification and significantly improve the function of parathyroid gland.

Key words: renal dialysis, parathyroid hormone, maintenance hemodialysis, lanthanum carbonate, calcium acetate, phosphorus and calcium metabolism