Abstract: Objective To compare the ultrasonographic radiomics features of breast carcinoma with medullary features
(CMF) and breast fibroadenoma (FA), and to comfirm the quantitative parameters of differential diagnosis so as to provide the
imaging basis for clinical diagnosis and treatment. Methods Data of ultrasonographic images containing 43 CMF lesions
and 129 FA lesions (control group) confirmed by pathology from January 2015 to December 2019 were retrospectively
analyzed. Radiomics features were evaluated and compared between the two groups. The area under the curve, cut-off value,
accuracy, sensitivity, specificity, positive predictive value and negative predictive value were calculated. Results The
aspect ratio (0.623 vs. 0.495) and concavity rate (0.107 vs. 0.047) were higher in CMF group than those of FA group. The gray
mean value (35.651 vs. 49.990), correlation (0.903 vs. 0.935) and homogeneity (0.780 vs. 0.811) were lower in CMF group
than those of FA group (P＜0.01). The AUC and accuracy of aspect ratio, concavity rate and correlation were relatively
higher, which can reach to 0.70. The sensitivity of aspect ratio, concavity rate, gray mean value, correlation and homogeneity
were higher, and which can be up to 0.80, but the specificity was lower. ConclusionThe aspect ratio, concavity rate, gray
mean value, correlation and homogeneity of ultrasonographic radiomics features provide evidence for the differential
diagnosis of breast carcinoma with medullary features and breast fibroadenoma, and which has certain clinical significance.

Key words: carcinoma, medullary, breast neoplasms, ultrasonography, fibroadenoma, diagnosis, differential, radiomics