Abstract: Objective　To understand the effect of lipid metabolism disorder on the function of vascular endothelial cells, microinflammatory state and coagulation function through the detection of VCAM-1 and hs-C-reactive protein (CRP)in children with primary nephrotic syndrome (PNS). Methods　Sixty-five children who met the PNS standard were selected as the case group, and 45 healthy children matched in gender and age were selected as the control group. The serum levels of VCAM-1 and hs-CRP were measured by enzyme-linked immunosorbent assay (ELISA) and immunoturbidimetry in PNS group and control group. The 24 hour urine protein quantity was measured by special protein analyzer in the two groups. The serum levels of albumin (ALB), triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), ApoA1, ApoB, lipoprotein a [(LP(a)], fibrinogen (Fb) and D-dimer were also measured by special protein analyzer. Pearson method was used to detect urinary protein, blood levels of ALB, TG, TC, LDL-C, HDL-C, ApoA1, ApoB, LP(a)， Fb, and D-dimer and their relationship with VCAM-1 and hs-CRP. Results　The levels of VCAM-1 and hs-CRP were significantly higher before treatment in the case group than those in the control group. The levels of VCAM-1 and hs-CRP were significantly lower after hormone treatment than those before treatment in the case group. The blood levels of VCAM-1 and hs-CRP were positively correlated with urinary protein, serum levels of TG, TC, LDL-C, ApoB, LP(a)， Fb and D-dimer (P＜0.05). There was a negative correlation between blood levels of VCAM-1 and serum levels of ALB and HDL-C (P＜0.05). Conclusion　The significant increase of VCAM-1 and hs-CRP levels in PNS indicates that there is endothelial cell injury and micro inflammation in PNS children at acute stage. The level of VCAM-1 and hs-CRP can predict and evaluate the micro inflammatory state, endothelial cell injury, hypercoagulable state and thrombosis of PNS.

Key words: nephrotic syndrome, vascular cell adhesion molecule-1, C-reactive protein, lipid metabolism, child