Clinical significance of serum expression of progranulin in non-traumatic osteonecrosis of femoral head

doi:10.11958/20220985

Abstract

Abstract:

Objective To explore the clinical value of serum progranulin (PGRN) in non-traumatic osteonecrosis of femoral head (NONFH). Methods A total of 75 patients with NONFH were selected as the NONFH group, and 67 healthy individuals matched for sex and age were selected as the healthy group. Serum PGRN concentration was detected by enzyme-linked immunosorbent assay. The visual analogue scale (VAS) and Harris score were used to evaluate the hip joint pain and function. The general data and imaging results were compared between the two groups. The serum PGRN levels of NONFH patients with different clinical characteristics were compared. The correlation between PGRN and clinical indicators was analyzed. Receiver operating characteristic (ROC) curve was used to analyze the diagnostic value of serum PGRN level in NONFH. Results The level of serum PGRN was significantly higher in the NONFH group than that in the healthy group (P<0.05). There was no significant difference in PGRN levels between NONFH patients with different etiologies. The level of PGRN was significantly higher in NONFH patients with bilateral necrosis than that in patients with unilateral necrosis, and the level of PGRN was significantly higher in NONFH patients with femoral head collapse than that in patients without collapse (P<0.05). The level of serum PGRN was positively correlated with ARCO stage (r_s=0.645) and VAS score of pain (r=0.694), but negatively correlated with Harris score (r=-0.732, P<0.01). ROC curve results showed that the area under the curve of PGRN for the diagnosis of NONFH was 0.786 (95%CI: 0.710-0.862, P<0.01), the optimal cut-off value was 14.55 μg/L, the sensitivity was 0.640 and the specificity was 0.910. Conclusion Serum PGRN level can reflect the severity of NONFH and has certain value in the diagnosis of NONFH.

Key words: femur head necrosis, biomarkers, progranulin, collapse of the femoral head

CLC Number:

R681.8

Figures/Tables 2

References 20

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组别	n	性别（男/女）	年龄（岁）	BMI （kg/m²）	PGRN （μg/L）
健康组	67	46/21	42.52±10.20	23.83±3.09	9.99±3.59
NONFH组	75	54/21	42.96±9.97	24.00±3.09	18.94±10.30
χ²或t		0.190	0.258	0.322	6.750^＊＊

组别	n	性别（男/女）	年龄（岁）	BMI （kg/m²）	PGRN （μg/L）
健康组	67	46/21	42.52±10.20	23.83±3.09	9.99±3.59
NONFH组	75	54/21	42.96±9.97	24.00±3.09	18.94±10.30
χ²或t		0.190	0.258	0.322	6.750^＊＊