Tianjin Medical Journal ›› 2023, Vol. 51 ›› Issue (3): 307-310.doi: 10.11958/20220680
• Clinical Research • Previous Articles Next Articles
YANG Hongxiu(), YUAN Baojun(
), LIU Li, ZHAO Ying, ZHANG Feifei, TONG Yanyan, ZHANG Huifen
Received:
2022-05-19
Revised:
2022-09-13
Published:
2023-03-15
Online:
2023-03-02
Contact:
YUAN Baojun
E-mail:287361401@qq.com;ybj25999@163.com
YANG Hongxiu, YUAN Baojun, LIU Li, ZHAO Ying, ZHANG Feifei, TONG Yanyan, ZHANG Huifen. Relationship between serum CTRP1, CTRP5 and CTRP1/CTRP5 levels and unstable angina pectoris[J]. Tianjin Medical Journal, 2023, 51(3): 307-310.
CLC Number:
组别 | n | 性别(男/女) | 年龄(岁) | 高血压 | 糖尿病 | 高血脂 | GS积分 | TG(mmol/L) | TC(mmol/L) | HDL-C(mmol/L) | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
对照组 | 47 | 16/31 | 58.62±6.76 | 12(25.5) | 0(0.0) | 13(27.7) | 0(0,0) | 1.33(0.81,1.84) | 4.47(3.90,4.95) | 1.20(1.03,1.51) | ||||||
UAP组 | 103 | 67/36 | 64.81±8.73 | 63(61.2) | 35(34.0) | 43(41.4) | 39(24,54) | 1.52(1.08,2.25) | 4.55(3.97,5.62) | 1.09(0.94,1.22) | ||||||
χ2、t或Z | 12.553** | 4.305** | 16.391** | 20.832** | 2.738 | 9.964** | 1.935 | 1.230 | 3.126** | |||||||
组别 | LDL-C(mmol/L) | GLU(mmol/L) | CRP(mmol/L) | CTRP1(μg/L) | CTRP5(μg/L) | CTRP1/CTRP5 | ||||||||||
对照组 | 2.55(2.32,3.13) | 4.47(4.21,4.79) | 1.00(0.50,1.90) | 802.00(708.67,865.33) | 42.96(36.38,47.82) | 18.32(16.88,20.79) | ||||||||||
UAP组 | 2.92(2.45,3.66) | 5.44(4.70,6.82) | 2.20(1.20,3.80) | 925.33(845.33,975.33) | 46.25(43.11,48.92) | 19.73(18.89,20.55) | ||||||||||
χ2、t或Z | 2.559* | 6.224** | 3.910** | 5.043** | 2.579* | 2.461* |
Tab.1 Comparison of general data between the two groups
组别 | n | 性别(男/女) | 年龄(岁) | 高血压 | 糖尿病 | 高血脂 | GS积分 | TG(mmol/L) | TC(mmol/L) | HDL-C(mmol/L) | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
对照组 | 47 | 16/31 | 58.62±6.76 | 12(25.5) | 0(0.0) | 13(27.7) | 0(0,0) | 1.33(0.81,1.84) | 4.47(3.90,4.95) | 1.20(1.03,1.51) | ||||||
UAP组 | 103 | 67/36 | 64.81±8.73 | 63(61.2) | 35(34.0) | 43(41.4) | 39(24,54) | 1.52(1.08,2.25) | 4.55(3.97,5.62) | 1.09(0.94,1.22) | ||||||
χ2、t或Z | 12.553** | 4.305** | 16.391** | 20.832** | 2.738 | 9.964** | 1.935 | 1.230 | 3.126** | |||||||
组别 | LDL-C(mmol/L) | GLU(mmol/L) | CRP(mmol/L) | CTRP1(μg/L) | CTRP5(μg/L) | CTRP1/CTRP5 | ||||||||||
对照组 | 2.55(2.32,3.13) | 4.47(4.21,4.79) | 1.00(0.50,1.90) | 802.00(708.67,865.33) | 42.96(36.38,47.82) | 18.32(16.88,20.79) | ||||||||||
UAP组 | 2.92(2.45,3.66) | 5.44(4.70,6.82) | 2.20(1.20,3.80) | 925.33(845.33,975.33) | 46.25(43.11,48.92) | 19.73(18.89,20.55) | ||||||||||
χ2、t或Z | 2.559* | 6.224** | 3.910** | 5.043** | 2.579* | 2.461* |
组别 | n | CTRP1(μg/L) | CTRP5(μg/L) | CTRP1/CTRP5 |
---|---|---|---|---|
轻度狭窄组 | 53 | 888.67(812.00,943.67) | 45.47(42.96,47.27) | 19.47(18.60,20.27) |
重度狭窄组 | 50 | 950.33(882.83,1 000.33) | 47.43(43.12,50.02) | 20.06(19.06,20.58) |
Z | 2.874** | 2.244* | 1.729 |
Tab.2 Comparison of serum CTRP1, CTRP5 and CTRP1/CTRP5 levels between the two groups of UAP patients
组别 | n | CTRP1(μg/L) | CTRP5(μg/L) | CTRP1/CTRP5 |
---|---|---|---|---|
轻度狭窄组 | 53 | 888.67(812.00,943.67) | 45.47(42.96,47.27) | 19.47(18.60,20.27) |
重度狭窄组 | 50 | 950.33(882.83,1 000.33) | 47.43(43.12,50.02) | 20.06(19.06,20.58) |
Z | 2.874** | 2.244* | 1.729 |
组别 | n | CTRP1(μg/L) | CTRP5(μg/L) | CTRP1/CTRP5 |
---|---|---|---|---|
单支病变组 | 20 | 885.33(798.67,922.00) | 45.78(40.38,47.31) | 19.45(18.64,20.89) |
双支病变组 | 46 | 913.67(846.17,968.67) | 45.94(42.88,47.98) | 19.67(18.68,20.43) |
多支病变组 | 37 | 948.67(882.00,1 002.00)a | 47.51(44.53,49.86) | 19.97(19.08,20.55) |
H | 7.802* | 5.481 | 0.768 |
Tab.3 Comparison of serum CTRP1, CTRP5 and CTRP1/CTRP5 levels between the three groups of UAP patients
组别 | n | CTRP1(μg/L) | CTRP5(μg/L) | CTRP1/CTRP5 |
---|---|---|---|---|
单支病变组 | 20 | 885.33(798.67,922.00) | 45.78(40.38,47.31) | 19.45(18.64,20.89) |
双支病变组 | 46 | 913.67(846.17,968.67) | 45.94(42.88,47.98) | 19.67(18.68,20.43) |
多支病变组 | 37 | 948.67(882.00,1 002.00)a | 47.51(44.53,49.86) | 19.97(19.08,20.55) |
H | 7.802* | 5.481 | 0.768 |
变量 | β | SE | Wald χ2 | P | OR(95%CI) |
---|---|---|---|---|---|
性别 | -2.074 | 0.607 | 11.692 | 0.001 | 0.126(0.038~0.413) |
年龄 | 0.135 | 0.044 | 9.489 | 0.002 | 1.145(1.050~1.247) |
GLU | 1.715 | 0.535 | 10.271 | 0.001 | 5.558(1.947~15.865) |
HDL-C | -2.401 | 1.023 | 5.508 | 0.019 | 0.091(0.012~0.673) |
LDL-C | 1.014 | 0.405 | 6.272 | 0.012 | 2.758(1.247~6.101) |
CTRP1 | 0.007 | 0.003 | 8.114 | 0.004 | 1.007(1.002~1.012) |
常数项 | -18.920 | 4.740 | 15.932 | <0.001 | 0.000 |
Tab.4 Analysis of influencing factors of UAP
变量 | β | SE | Wald χ2 | P | OR(95%CI) |
---|---|---|---|---|---|
性别 | -2.074 | 0.607 | 11.692 | 0.001 | 0.126(0.038~0.413) |
年龄 | 0.135 | 0.044 | 9.489 | 0.002 | 1.145(1.050~1.247) |
GLU | 1.715 | 0.535 | 10.271 | 0.001 | 5.558(1.947~15.865) |
HDL-C | -2.401 | 1.023 | 5.508 | 0.019 | 0.091(0.012~0.673) |
LDL-C | 1.014 | 0.405 | 6.272 | 0.012 | 2.758(1.247~6.101) |
CTRP1 | 0.007 | 0.003 | 8.114 | 0.004 | 1.007(1.002~1.012) |
常数项 | -18.920 | 4.740 | 15.932 | <0.001 | 0.000 |
指标 | cut-off值 | 敏感度 (%) | 特异度 (%) | Youden 指数 | AUC(95%CI) |
---|---|---|---|---|---|
CTRP1 | 870.33 μg/L | 68.9 | 78.7 | 0.478 | 0.757(0.675~0.839) |
CTRP5 | 43.04 μg/L | 77.7 | 51.1 | 0.288 | 0.631(0.526~0.737) |
CTRP1/CTRP5 | 18.41 | 84.5 | 51.1 | 0.356 | 0.625(0.516~0.735) |
表5 The diagnostic efficacy of CTRP1, CTRP5 and CTRP1/CTRP5 in predicting UAP
指标 | cut-off值 | 敏感度 (%) | 特异度 (%) | Youden 指数 | AUC(95%CI) |
---|---|---|---|---|---|
CTRP1 | 870.33 μg/L | 68.9 | 78.7 | 0.478 | 0.757(0.675~0.839) |
CTRP5 | 43.04 μg/L | 77.7 | 51.1 | 0.288 | 0.631(0.526~0.737) |
CTRP1/CTRP5 | 18.41 | 84.5 | 51.1 | 0.356 | 0.625(0.516~0.735) |
[1] | SELDIN M M, PETERSON J M, BYERLY M S, et al.Myonectin(CTRP15),a novel myokine that links skeletal muscle to systemic lipid homeostasis[J]. Biol Chem, 2012, 287(15):11968-11980. doi:10.1074/jbc.M111.336834. |
[2] | TANG J N, SHEN D L, LIU C L, et al. Plasma levels of C1q/TNF-related protein 1 and interleukin 6 in patients with acute coronary syndrome or stable angina pectoris[J]. Am J Med Sci, 2015, 349(2):130-136. doi:10.1097/MAJ.0000000000000378. |
[3] | 王景志. 不稳定型心绞痛患者冠状动脉支架植入24 h血清CTRP5水平的变化[D]. 石家庄: 河北医科大学, 2017. |
WANG J Z. The change of serum CTRP5 in patients with unstable angina pectoris in 24 h after percutaneous coronary intervention[D]. Shijiazhuang: Hebei Medical University, 2017. | |
[4] | MAJIDI Z, EMAMGHOLIPOUR S, OMIDIFAR A, et al. The circulating levels of CTRP1 and CTRP5 are associated with obesity indices and carotid intima-media thickness (cIMT) value in patients with type 2 diabetes:a preliminary study[J]. Diabetol Metab Syndr, 2021, 13(1):14. doi:10.1186/s13098-021-00631-w. |
[5] | 中华医学会心血管病学分会, 中华心血管病杂志编辑委员会. 非ST段抬高型急性冠状动脉综合征诊断和治疗指南(2016)[J]. 中华心血管病杂志, 2017, 45(5):359-376. |
Chinese Society of Cardiology,Editorial Board of Chinese Journal of Cardiovascular Disease. Guidelines for diagnosis and treatment of non-ST-segment elevation acute coronary syndrome(2016)[J]. Chin J Cardiol, 2017, 45(5):359-376. doi:10.3760/cma.j,issn.0253-3758.2017.05.003. | |
[6] | FERGUSON J F, HINKLE C C, MEHTA N N, et al. Translational studies of lipoprotein-associated phospholipase A2 in inflammation and atherosclerosis[J]. Am Coll Cardiol, 2012, 59(8):764-772. doi:10.1016/j.jacc.2011.11.019. |
[7] | KIM D, PARK S Y. C1q and TNF related protein 1 regulates expression of inflammatory genes in vascular smooth muscle cells[J]. Genes Genomics, 2019, 41(4):397-406. doi:10.1007/s13258-018-0770-5. |
[8] | ZHANG Y, LIU C, LIU J, et al. Implications of C1q/TNF-related protein superfamily in patients with coronary artery disease[J]. Sci Rep, 2020, 10(1):878. doi:10.1038/s41598-020-57877-z. |
[9] | 贾磊, 高钊. 冠心病不稳定型心绞痛合并冠脉狭窄患者CRP、Angptls 2、CTRP1水平变化及临床意义[J]. 海南医学, 2020, 31(8):966-968. |
JIA L, GAO Z. Detection of CRP, Angptls 2,CTRP1 in patients with unstable angina pectoris complicated with coronary artery disease and its diagnostic value[J]. Hainan Med J, 2020, 31(8):966-968. doi:10.3969/j.issn.1003-6350.2020.08.005. | |
[10] | 林文婷, 曾敏, 陈积雄, 等. 血清C1q、CTRP1与冠状动脉粥样硬化性心脏病的相关性研究[J]. 中国循证心血管医学杂志, 2019, 11(5):534-536,540. |
LIN W T, ZENG M, CHEN J X, et al. Correlation between serum C1q, CTRP1 and coronary atherosclerotic heart disease[J]. Chin J Evid Based Cardiovasc, 2019, 11(5):534-536,540. doi:10.3969/j.issn.1674-4055.2019.05.06. | |
[11] | 刘彩红, 张彦伟, 刘雯霞, 等. 血清CTRP1和CTRP7水平与冠心病合并糖尿病的关系[J]. 中国病理生理杂志, 2020, 36(8):1470-1475. |
LIU C H, ZHANG Y W, LIU W X, et al. Serum CTRP1 and CTRP7 levels are associated with coronary atherosclerotic heart disease and diabetes mellitus[J]. Chinese Journal of Pathophysiology, 2020, 36(8):1470-1475. doi:10.3969/j.issn.1000-4718.2020.08.019. | |
[12] | SHEN Y, LI C, ZHANG R Y, et al. Association of increased serum CTRP5 levels with in-stent restenosis after coronary drug-eluting stent implantation:CTRP5 promoting inflammation,migration and proliferation in vascular smooth muscle cells[J]. Int J Cardiol, 2017, 228:129-136. doi:10.1016/j.ijcard.2016.11.034. |
[13] | 张晓迪. 冠心病合并糖尿病患者血清CTRP-5水平变化及临床意义[D]. 石家庄: 河北医科大学, 2017. |
ZHANG X D. Serum level of CTRP-5 levels in coronary heart disease combined with TYPE-2 diabetes mellitus[J]. Shijiazhuang:Hebei Medical University, 2017. | |
[14] | ZHANG H, LIU M, REN T, et al. Associations between carotid artery plaque score,carotid hemodynamics and coronary heart disease[J]. Int J Environ Res Public Health, 2015, 12(11):14275-14284. doi:10.3390/ijerph121114275. |
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