Expression levels of plasma SIRT-1 and syndecan-1 in patients with sepsis-induced ALI/ARDS and their effect on prognosis

doi:10.11958/20221108

Abstract

CLC Number:

R563.8

Figures/Tables 5

References 21

[1]	LONG M E, MALLAMPALLI R K, HOROWITZ J C. Pathogenesis of pneumonia and acute lung injury[J]. Clin Sci (Lond), 2022, 136(10):747-769. doi:10.1042/CS20210879.
[2]	MCVEY M J, STEINBERG B E, GOLDENBERG N M. Inflammasome activation in acute lung injury[J]. Am J Physiol Lung Cell Mol Physiol, 2021, 320(2):L165-L178. doi:10.1152/ajplung.00303.2020.
[3]	MOKRA D. Acute lung injury-from pathophysiology to treatment[J]. Physiol Res, 2020, 69(Suppl 3):S353-S366. doi:10.33549/physiolres.934602.
[4]	CHEN C, ZHOU M, GE Y, et al. SIRT1 and aging related signaling pathways[J]. Mech Ageing Dev, 2020, 187(4):111215. doi:10.1016/j.mad.2020.111215.
[5]	赵维, 刘俊彦, 李玉英. SIRT1减弱对脂多糖致急性呼吸窘迫综合征小鼠的促炎作用[J]. 中华肺部疾病杂志(电子版), 2017, 10(2):163-167.
	ZHAO W, LIU J Y, LI Y Y. Effect of SIRT1 weakening on inflammation in mice with acute respiratory distress syndrome induced by lipopolysaccharide[J]. Chin J Lung Dis(Electronic Edition), 2017, 10(2):163-167. doi:10.3877/cma.j.issn.1674-6902.2017.02.010.
[6]	RANGARAJAN S, RICHTER J R, RICHTER R P, et al. Heparanase-enhanced shedding of syndecan-1 and its role in driving disease pathogenesis and progression[J]. J Histochem Cytochem, 2020, 68(12):823-840. doi:10.1369/0022155420937087.
[7]	LAMBERT J, MAKIN K, AKBAREIAN S, et al. ADAMTS-1 and syndecan-4 intersect in the regulation of cell migration and angiogenesis[J]. J Cell Sci, 2020, 133(7):jcs235762. doi:10.1242/jcs.235762.
[8]	SHANKAR-HARI M, PHILLIPS G S, LEVY M L, et al. Developing a new definition and assessing new clinical criteria for septic shock: for the third international consensus definitions for sepsis and septic shock (Sepsis-3)[J]. JAMA, 2016, 315(8):775-787. doi:10.1001/jama.2016.0289.
[9]	中华医学会重症医学分会. 急性肺损伤/急性呼吸窘迫综合征诊断和治疗指南(2006)[J]. 中华急诊医学杂志, 2007, 16(4):343-349.
	Critical Care Branch of CMA. Guidelines for diagnosis and treatment of acute lung injury/acute respiratory distress syndrome(2006)[J]. Chin J Emerg Med, 2007, 16(4):343-349. doi:10.3760/j.issn:1671-0282.2007.04.002.
[10]	SONG H, CHEN Q, XIE S, et al. GDF-15 prevents lipopolysaccharide-mediated acute lung injury via upregulating SIRT1[J]. Biochem Biophys Res Commun, 2020, 526(2):439-446. doi:10.1016/j.bbrc.2020.03.103.
[11]	FU C, HAO S, XU X, et al. Activation of SIRT1 ameliorates LPS-induced lung injury in mice via decreasing endothelial tight junction permeability[J]. Acta Pharmacol Sin, 2019, 40(5):630-641. doi:10.1038/s41401-018-0045-3.
[12]	YANG F, YAN J, LU Y, et al. MicroRNA-499-5p targets SIRT1 to aggravate lipopolysaccharide-induced acute lung injury[J]. Free Radic Res, 2021, 55(1):71-82. doi:10.1080/10715762.2020.1863393.
[13]	YANG Y, LI L. Depleting microRNA-146a-3p attenuates lipopolysaccharide-induced acute lung injury via up-regulating SIRT1 and mediating NF-κB pathway[J]. J Drug Target, 2021, 29(4):420-429. doi:10.1080/1061186X.2020.1850738.
[14]	LEI J, SHEN Y, XV G, et al. Aloin suppresses lipopolysaccharide-induced acute lung injury by inhibiting NLRP3/NF-κB via activation of SIRT1 in mice[J]. Immunopharmacol Immunotoxicol, 2020, 42(4):306-313. doi:10.1080/08923973.2020.1765373.
[15]	AN N, YANG T, ZHANG X X, et al. Bergamottin alleviates LPS-induced acute lung injury by inducing SIRT1 and suppressing NF-κB[J]. Innate Immun, 2021, 27(7/8):543-552. doi:10.1177/17534259211062553.
[16]	SOLIMAN N A, YUSSIF S M, SHEBL A M. Syndecan-1 could be added to hormonal receptors and HER2/neu in routine assessment of invasive breast carcinoma, relation of its expression to prognosis and clinicopathological parameters[J]. Pathol Res Pract, 2019, 215(5):977-982. doi:10.1016/j.prp.2019.02.003.
[17]	IBA T, LEVY J H. Derangement of the endothelial glycocalyx in sepsis[J]. J Thromb Haemost, 2019, 17(2):283-294. doi:10.1111/jth.14371.
[18]	齐颖, 李真玉, 王斌, 等. Wnt5a与Syndecan-1在小鼠脓毒症致急性肺损伤中的表达研究[J]. 中国急救医学, 2017, 37(1):43-48,封3.
	QI Y, LI Z Y, WANG B, et al. The expression and significance of Wnt5a and Syndecan-1 in sepsis-induced acute lung injury of mice[J]. Chin J Crit Care Med, 2017, 37(1):43-48,Cover 3. doi:10.3969/j.issn.1002-1949.2017.01.010.
[19]	LI H, HAO Y, YANG L L, et al. MCTR1 alleviates lipopolysaccharide-induced acute lung injury by protecting lung endothelial glycocalyx[J]. J Cell Physiol, 2020, 235(10):7283-7294. doi:10.1002/jcp.29628.
[20]	VIGNON P, EVRARD B, ASFAR P, et al. Fluid administration and monitoring in ARDS: which management?[J]. Intensive Care Med, 2020, 46(12):2252-2264. doi:10.1007/s00134-020-06310-0.
[21]	KAJITA Y, TERASHIMA T, MORI H, et al. A longitudinal change of syndecan-1 predicts risk of acute respiratory distress syndrome and cumulative fluid balance in patients with septic shock: A preliminary study[J]. J Intensive Care, 2021, 9(1):27. doi:10.1186/s40560-021-00543-x.

组别	n	SIRT-1	syndecan-1
对照组	50	1.42±0.36	211.24±57.26
ALI/ARDS组	106	0.81±0.27	501.67±81.32
t		11.790^＊＊	22.719^＊＊

组别	n	SIRT-1	syndecan-1
对照组	50	1.42±0.36	211.24±57.26
ALI/ARDS组	106	0.81±0.27	501.67±81.32
t		11.790^＊＊	22.719^＊＊

组别	n	男性	年龄（岁）	BMI （kg/m²）	原发疾病				APACHEⅡ （分）	LIS （分）	SIRT-1 （μg/L）	syndecan-1 （μg/L）
组别	n	男性	年龄（岁）	BMI （kg/m²）	呼吸道感染	尿路感染	腹腔感染	其他	APACHEⅡ （分）	LIS （分）	SIRT-1 （μg/L）	syndecan-1 （μg/L）
生存组	66	36（54.55）	56.71±9.42	22.25±2.31	30（45.45）	14（21.21）	12（18.18）	10（15.15）	19.89±6.42	1.98±0.22	0.96±0.27	451.19±72.35
死亡组	40	25（62.50）	58.04±9.89	22.01±2.08	22（55.00）	8（20.00）	7（17.50）	3（7.50）	28.43±9.33	2.28±0.25	0.56±0.22	584.97±90.31
t		0.645	0.691	0.538	1.676				5.570^＊＊	6.246^＊＊	7.909^＊＊	8.391^＊＊

组别	n	男性	年龄（岁）	BMI （kg/m²）	原发疾病				APACHEⅡ （分）	LIS （分）	SIRT-1 （μg/L）	syndecan-1 （μg/L）
组别	n	男性	年龄（岁）	BMI （kg/m²）	呼吸道感染	尿路感染	腹腔感染	其他	APACHEⅡ （分）	LIS （分）	SIRT-1 （μg/L）	syndecan-1 （μg/L）
生存组	66	36（54.55）	56.71±9.42	22.25±2.31	30（45.45）	14（21.21）	12（18.18）	10（15.15）	19.89±6.42	1.98±0.22	0.96±0.27	451.19±72.35
死亡组	40	25（62.50）	58.04±9.89	22.01±2.08	22（55.00）	8（20.00）	7（17.50）	3（7.50）	28.43±9.33	2.28±0.25	0.56±0.22	584.97±90.31
t		0.645	0.691	0.538	1.676				5.570^＊＊	6.246^＊＊	7.909^＊＊	8.391^＊＊

变量	β	SE	Wald χ²	P	OR（95%CI）
APACHEⅡ	0.542	0.245	4.894	0.027	1.719（1.064~2.779）
LIS	0.767	0.284	7.294	0.007	2.153（1.234~3.757）
SIRT-1	-0.271	0.118	5.274	0.022	0.763（0.605~0.961）
syndecan-1	0.891	0.321	7.705	0.006	2.438（1.299~4.573）
常数项	0.357	0.174	4.210	0.040	1.429

Expression levels of plasma SIRT-1 and syndecan-1 in patients with sepsis-induced ALI/ARDS and their effect on prognosis

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指标	AUC及95%CI	截断值	敏感度（%）	特异度（%）	约登指数
APACHEⅡ	0.756（0.661~0.851）	24分	75.00	71.21	0.462
LIS	0.762（0.668~0.855）	2分	57.50	86.36	0.439
SIRT-1	0.860（0.791~0.930）	0.77 μg/L	77.50	84.85	0.624
syndecan-1	0.870（0.800~0.940）	495.75 μg/L	82.50	81.82	0.643

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