Tianjin Medical Journal ›› 2025, Vol. 53 ›› Issue (4): 393-397.doi: 10.11958/20250076
• Clinical Research • Previous Articles Next Articles
HE Qianqian(), HUANG Han, LIANG Lihong, WU Linlin, LIANG Dongge(
)
Received:
2025-01-08
Revised:
2025-01-24
Published:
2025-04-15
Online:
2025-04-17
Contact:
△ E-mail:HE Qianqian, HUANG Han, LIANG Lihong, WU Linlin, LIANG Dongge. Expression levels and clinical significance of Galectin-3, IL-1β and IL-9 in peripheral blood of children with refractory mycoplasma pneumoniae pneumonia[J]. Tianjin Medical Journal, 2025, 53(4): 393-397.
CLC Number:
组别 | n | 男性 | 年龄/岁 | 住院时间/d | 热程/d | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
GMPP组 | 128 | 72(56.25) | 7.25±2.30 | 7.50±1.85 | 8.05±2.15 | |||||||||
RMPP组 | 132 | 76(57.58) | 7.40±2.42 | 7.95±2.25 | 11.23±2.30 | |||||||||
t或χ2 | 0.047 | 0.512 | 1.759 | 11.509** | ||||||||||
组别 | 喘息 | 胸腔积液 | 胸膜增厚 | 肺外并发症 | 肺部湿啰音 | |||||||||
GMPP组 | 21(16.41) | 22(17.19) | 15(11.72) | 8(6.25) | 23(17.97) | |||||||||
RMPP组 | 28(21.21) | 25(18.94) | 18(13.64) | 22(16.67) | 29(21.97) | |||||||||
χ2 | 0.981 | 0.135 | 0.216 | 6.908** | 0.650 | |||||||||
组别 | CRP/(mg/L) | TNF-α/(μg/L) | PCT/(μg/L) | |||||||||||
GMPP组 | 14.75±3.30 | 2.40±0.64 | 0.12±0.03 | |||||||||||
RMPP组 | 18.48±4.09 | 3.12±0.92 | 0.15±0.04 | |||||||||||
t | 8.078** | 7.305** | 6.825** |
Tab.1 2组患儿临床资料比较
组别 | n | 男性 | 年龄/岁 | 住院时间/d | 热程/d | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
GMPP组 | 128 | 72(56.25) | 7.25±2.30 | 7.50±1.85 | 8.05±2.15 | |||||||||
RMPP组 | 132 | 76(57.58) | 7.40±2.42 | 7.95±2.25 | 11.23±2.30 | |||||||||
t或χ2 | 0.047 | 0.512 | 1.759 | 11.509** | ||||||||||
组别 | 喘息 | 胸腔积液 | 胸膜增厚 | 肺外并发症 | 肺部湿啰音 | |||||||||
GMPP组 | 21(16.41) | 22(17.19) | 15(11.72) | 8(6.25) | 23(17.97) | |||||||||
RMPP组 | 28(21.21) | 25(18.94) | 18(13.64) | 22(16.67) | 29(21.97) | |||||||||
χ2 | 0.981 | 0.135 | 0.216 | 6.908** | 0.650 | |||||||||
组别 | CRP/(mg/L) | TNF-α/(μg/L) | PCT/(μg/L) | |||||||||||
GMPP组 | 14.75±3.30 | 2.40±0.64 | 0.12±0.03 | |||||||||||
RMPP组 | 18.48±4.09 | 3.12±0.92 | 0.15±0.04 | |||||||||||
t | 8.078** | 7.305** | 6.825** |
组别 | n | Galectin-3 | IL-1β | IL-9 |
---|---|---|---|---|
GMPP组 | 128 | 5.51±1.37 | 5.86±1.41 | 57.32±12.56 |
RMPP组 | 132 | 7.47±1.92 | 8.10±2.02 | 75.84±18.20 |
t | 9.450** | 10.339** | 9.522** |
Tab.2 2组患儿外周血Galectin-3、IL-1β、IL-9水平比较 (ng/L,$\bar{x} \pm s$)
组别 | n | Galectin-3 | IL-1β | IL-9 |
---|---|---|---|---|
GMPP组 | 128 | 5.51±1.37 | 5.86±1.41 | 57.32±12.56 |
RMPP组 | 132 | 7.47±1.92 | 8.10±2.02 | 75.84±18.20 |
t | 9.450** | 10.339** | 9.522** |
变量 | Galectin-3 | IL-1β | IL-9 |
---|---|---|---|
热程 | 0.507** | 0.494** | 0.497** |
肺外并发症 | 0.512** | 0.512** | 0.516** |
CRP | 0.526** | 0.548** | 0.539** |
TNF-α | 0.538** | 0.536** | 0.509** |
PCT | 0.517** | 0.527** | 0.521** |
Tab.3 RMPP患儿外周血的Galectin-3、IL-1β、IL-9水平与临床因素的相关性 (r/rs)
变量 | Galectin-3 | IL-1β | IL-9 |
---|---|---|---|
热程 | 0.507** | 0.494** | 0.497** |
肺外并发症 | 0.512** | 0.512** | 0.516** |
CRP | 0.526** | 0.548** | 0.539** |
TNF-α | 0.538** | 0.536** | 0.509** |
PCT | 0.517** | 0.527** | 0.521** |
变量 | β | SE | Wald χ2 | P | OR | OR 95%CI |
---|---|---|---|---|---|---|
Galectin-3 | 1.038 | 0.305 | 11.586 | 0.001 | 2.824 | 1.553~5.134 |
IL-1β | 1.069 | 0.401 | 7.109 | 0.008 | 2.913 | 1.327~6.393 |
IL-9 | 0.995 | 0.353 | 7.941 | 0.005 | 2.704 | 1.354~5.401 |
热程 | 0.076 | 0.215 | 0.125 | 0.724 | 1.079 | 0.708~1.644 |
肺外并发症 | 0.127 | 0.108 | 1.375 | 0.241 | 1.135 | 0.918~1.403 |
CRP | 0.133 | 0.126 | 1.111 | 0.292 | 1.142 | 0.892~1.462 |
TNF-α | 0.101 | 0.119 | 0.717 | 0.397 | 1.106 | 0.876~1.397 |
PCT | 0.143 | 0.154 | 0.865 | 0.352 | 1.154 | 0.853~1.561 |
常数项 | -30.319 | 7.369 | 9.961 | 0.001 | 0.000 |
Tab.4 GMPP进展为RMPP的影响因素分析
变量 | β | SE | Wald χ2 | P | OR | OR 95%CI |
---|---|---|---|---|---|---|
Galectin-3 | 1.038 | 0.305 | 11.586 | 0.001 | 2.824 | 1.553~5.134 |
IL-1β | 1.069 | 0.401 | 7.109 | 0.008 | 2.913 | 1.327~6.393 |
IL-9 | 0.995 | 0.353 | 7.941 | 0.005 | 2.704 | 1.354~5.401 |
热程 | 0.076 | 0.215 | 0.125 | 0.724 | 1.079 | 0.708~1.644 |
肺外并发症 | 0.127 | 0.108 | 1.375 | 0.241 | 1.135 | 0.918~1.403 |
CRP | 0.133 | 0.126 | 1.111 | 0.292 | 1.142 | 0.892~1.462 |
TNF-α | 0.101 | 0.119 | 0.717 | 0.397 | 1.106 | 0.876~1.397 |
PCT | 0.143 | 0.154 | 0.865 | 0.352 | 1.154 | 0.853~1.561 |
常数项 | -30.319 | 7.369 | 9.961 | 0.001 | 0.000 |
变量 | AUC | 95%CI | 截断值 | 敏感度/% | 特异度/% |
---|---|---|---|---|---|
Galectin-3 | 0.852 | 0.806~0.897 | 6.05 ng/L | 0.64 | 0.92 |
IL-1β | 0.813 | 0.762~0.864 | 6.79 ng/L | 0.73 | 0.76 |
IL-9 | 0.812 | 0.760~0.863 | 62.15 ng/L | 0.80 | 0.70 |
联合 | 0.949 | 0.925~0.973 | 0.88 | 0.89 |
Tab.5 外周血Galectin-3、IL-1β、IL-9水平对RMPP的预测价值
变量 | AUC | 95%CI | 截断值 | 敏感度/% | 特异度/% |
---|---|---|---|---|---|
Galectin-3 | 0.852 | 0.806~0.897 | 6.05 ng/L | 0.64 | 0.92 |
IL-1β | 0.813 | 0.762~0.864 | 6.79 ng/L | 0.73 | 0.76 |
IL-9 | 0.812 | 0.760~0.863 | 62.15 ng/L | 0.80 | 0.70 |
联合 | 0.949 | 0.925~0.973 | 0.88 | 0.89 |
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