Abstract: Abstract: Objective　To investigate the expressions of circular RNA cerebellar degeneration-related protein 1 antisense (CDR1as) and microRNA-7 (miR-7) in the plasma of epileptic patients and their relationships with abnormal EEG. Methods　A total of 87 epileptic patients treated and hospitalized in the Second Affiliated Hospital of Xinxiang Medical College from December 2016 to December 2019 were selected as the study objects (observation group). According to the electroencephalograph (EEG) results, patients were divided into normal group (n=6), mild abnormal group (n=18), moderate abnormal group (n=37) and severe abnormal group (n=26). In addition, 90 healthy people in the same period were selected as the control group. The plasma levels of CDR1as and miR-7 were detected by real-time fluorescent quantitative PCR (qPCR). The plasma levels of interleukin 2 (IL-2), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) were detected by enzyme-linked immunosorbent assay (ELISA). Pearson's method was used to analyze the correlation between the levels of CDR1as, miR-7 and the levels of IL-2, TNF-α and IL-1β. Results　The levels of CDR1as, IL-2, TNF-α and IL-1β were significantly increased in the normal group, mild abnormal group, moderate abnormal group and severe abnormal group (P＜0.05), while the level of miR-7 was significantly decreased (P＜0.05). There was a positive correlation between the plasma levels of CDR1as and IL-2, TNF - α and IL-1 β in epileptic patients (P < 0.05). There was a negative correlation between the level of miR-7 and IL-2, TNF-α and IL-1β (P＜0.05). Conclusion　The plasma expressions of CDR1as and miR-7 are higher and lower in epileptic patients, respectively, and they are closely related to the levels of inflammatory factors and the abnormal degree of EEG, which may cause abnormal discharge of brain by influencing the  inflammatory response.

Key words: pilepsy, MicroRNAs, electroencephalography, interleukin-2;tumor necrosis factor-alpha, interleukin-1beta, cerebellar degeneration-related protein 1 antisense, miR-7