Abstract: Object To discuss the treatment of progressive stroke with hydroxyethyl starch combined Edaravone. Method A retrospective analysis of 100 patients with progressive stroke from Jan 2010 to Nov 2011. All of these paitents were randomly divided into two groups, 50 patients in each group. The treatment group was treated with hydroxyethyl starch and Edaravone on the base of routine treatment. The control group was just given the routine treatment. Both groups were treated for two weeks continuously. The National institute of Health Stroke Scale (NIHSS ) and Barthel index (BI) were measured before and after the treatment，the adverse reactions were evaluated. Results The scoreing of NIHSS and BI in treatment group were much higher than control group(P<0.05).The different of adverse reactions in both groups were not significant (P > 0.05 ). Conclusions The treatment of progressive stroke with hydroxyethyl starch combined Edaravone has sure curative effect, and no significant adverse reactions.

Key words: hydroxyethyl starch, Edaravone, progressive stroke