Abstract: Abstract Objective: To evaluate the effect of fluvastatin-probucol combined therapy on levels of serum lipid and hs-CRP in patients with acute coronary syndrome. Methods: A total of 60 patients with acute coronary syndrome were randomly divided into three groups, 20 patients in each group. The patients of group A were taken fluvastatin 40mg/d; the patients of group B were taken fluvastatin 80mg/d; and the patients of group C were taken fluvastatin 40mg/d and 250 mg of probucol twice a day. The serum levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and hs-CRP were examined before treatment. All of them were detected again after 3 months of treatment. Results: There were no significant differences in the levels of serum lipid and hs-CRP before treatment among three groups (P>0.05). After the 3 months follow-up, the levels of serum lipid and hs-CRP in group C were lower than group A (P<0.05); the levels of TC and HDL-C were lower than group B (P<0.05). There were no differences in the levels of TG and LDL-C between C and B groups (P>0.05). Compared with the pretreatment values, the levels of TC and LDL-C in group B and C were significantly decreased after the therapy of 3 months (P<0.01) and the level of TG in group C was also reduced (P<0.05); the level of hs-CRP was decreased after treatment in each group (P<0.05), especially in the group C (P<0.01). Conclusion: Combined treatment by fluvastatin and probucol or single high-dose fluvastatin therapy has intensive effect on lowing serum lipid and hs-CRP in ACS patiants. Especially, the combined theatment could further strengthen the efficacy.

Key words: Fluvastatin, Probucol, acute coronary syndrome, serum lipids, high sensitivity C-reactive protein